Blood tests of colitis and Crohn's disease is a relatively new and exciting development significantly added to the screening, diagnosis and management of ulcerative colitis and Crohn's disease. By distinguishing between them, it is possible to respond to medical care, make decisions about surgical options, and better predict risks of various complications. Antibodies against various proteins including Baker and Brewer's yeast (Saccharomyces cerevisiae) and bacteria such as Escherichia. E. coli (E. coli) is present in the blood of many people with Crohn's disease, but rarely in normal people. Antibodies to nuclear proteins, which are normal cell components, are mostly afflicted with ulcerative colitis, the majority of patients with Crohn's disease resemble ulcerative colitis rather than Crohn's disease and are rare in normal people .
Antibody tests or serologic tests are blood tests that look for disease markers. Serological markers or antibody tests for ulcerative colitis and Crohn's disease are pANCA and ASCA, OmpC and CBir1 Flagelin, respectively. The latter three clonal blood tests are only available in one laboratory of Prometheus Laboratories, Inc.
Ulcerative colitis is an unknown cause of chronic inflammatory bowel disease (IBD) with only colon. Although it rarely affects the upper part of the colon and causes intestinal obstruction (obstruction) and perforation (rupture), it often causes severe diarrhea, blood in the blood, weight loss, abdominal pain, arthralgia or arthritis, skin rash, Includes eye inflammation and severe liver damage known as primary sclerosing cholangitis leading to liver cirrhosis and liver cancer in some cases. Ulcerative colitis can be cured by Crohn's disease rather than complete removal of the colon.
Crohn's disease can also cause colitis, but it usually also affects the end of the small intestine called ileum (ileitis or local enteritis). If Crohn affects only the colon, it may be difficult to distinguish it from ulcerative colitis, but Crohn tends to affect ulcerative colitis in the colon but ulcerative colitis is continuous There is sex. Crohn's disease affects the gastrointestinal tract anywhere from the mouth to the anus and can not be cured by removing the colon. It is also associated with intestinal stenosis (stenosis), which often results in obstruction requiring surgery. It can also be associated with fistulas which are abnormal connections to other organs and skin of the intestine, or to treat Crohn's disease from ulcerative colitis which may lead to abscess or perforation distinction from surgical approach There are different things to do and the types of complications that can occur can vary widely.
Traditionally, the diagnosis of ulcerative colitis and Crohn's disease is highly accurate by colonoscopy to confirm the involvement of other parts of the intestinal tract or the appearance of the colon on X-rays. Diagnosis is confirmed by a typical pattern of intestinal inflammation, as seen under a microscope on the tissue obtained by biopsy during colonoscopy. However, before blood tests became feasible, about 10% of IBD patients could not differentiate between ulcerative colitis and Crohn's disease, so it was diagnosed as indeterminate colitis.
PANCA, anti-ASCA, anti-OmpC, and anti-CBir1 fratellin antibodies are currently available for blood tests. PANCA is a peripheral anti-nuclear antibody. It is an abnormal antibody to the nuclear protein of the cell and is sensitive and specific for ulcerative colitis. Neutrophil specific PANCA ELISA (NSNA) is a feature of diseases such as UC that is most positive in a small portion of patients with ulcerative colitis (UC) and Crohn's disease. Immunofluorescent cell staining of neutrophils (NSNA IFA) and enzyme Dnase test (susceptible to NSNA DNase) is also performed as part of Promethean IBD Serology 7. The latter test is a cyst (cyst) that arises when my colon is removed due to ulcerative colitis that does not respond to inflammatory treatment of rectal sachets when present at high levels.
ASCA is an anti-Saccharomyces cerevisiae antibody. Saccharomyces cerevisiae is a yeast of Brewer or Baker. Crohn's disease patients have a high prevalence of abnormal antibodies against this yeast. Some people suggest that Candida albicans somehow plays a role in this abnormal reaction in some way. A few people with celiac disease cause this antibody to be present in the antibody in the absence of signs of Crohn's disease. OmpC is an abbreviation for antibodies that bacteria develop in the outer membrane porin protein of E. coli in many patients with Crohn's disease, but that bacterium is not considered to be the cause of Crohn's disease. Just recently, Prometheus Laboratories added antibody testing of certain proteins on bacteria that make up bacterial flagellum or hair-like structures, allowing for the transfer and attachment of enteric bacteria called CBir1 flagellin.
Future blood tests may include antibodies against specific sugar (mannose) residues in the cell wall of yeast Saccharomyces cerevisiae. Anti-laminaribioside and anti-chitobioside antibodies have recently been reported to exist in anti-ASCA negative Crohn's disease patients who may further enhance the ability to distinguish from patients with ulcerative colitis. This is also interesting due to public concern about doubts and role of sugars, glycans and yeast in IBD. In particular, a general literature report on the success of carbohydrate-specific diets in IBD.
If you are undergoing diagnosis of ulcerative colitis or Crohn's disease, these blood tests will be extremely useful for your treatment. If you have unexplained abdominal pain, diarrhea, or blood on your flight, you need to consider these tests. Upon undergoing a diagnosis of Irritable Bowel Syndrome, these tests may exclude ulcerative colitis and Crohn's disease. Since 10% of people with ulcerative colitis and Crohn's disease may also have celiac disease, celiac blood tests should also be considered. Lactose intolerance is also common in IBD, IBS and celiac disease.
For future useful information on Korresses, Crohn's disease, celiac disease, food allergy, food intolerance, eating habits sensitivity, eosinophilic esophagitis and irritable bowel syndrome, Dr. Scott Lewey, a food allergist specialist Information on colitis and Crohn's disease can also be obtained from the Crohn's and Colitis Foundation (CCFA, http://www.ccfa.org) Dr. Scot Lewey It is a member of the Medical Advisory Board of CCFA's Rocky Mountain Chapter For more information on Prometheus Laboratories Inc., please visit http://www.prometheuslabs.com Detailed explanation of blood tests is given below It is described in another article in the reference.
Abreu MT et al. Use of serologic examination in Crohn's disease. Clinical gastroenterology and liver pathology. Volume 4, No. 3, 2001
Dotan I et al. Antibodies against laminaribioside and chitobioside are novel serological markers in Crohn's disease. Gastroenterology. Vol. 131, No. 2 2006
Mei, L et al. Familial Expression of Anti - Escherichia coli Outer Membrane Polin C in Relatives of Crohn 's Disease. Gastroenterology. Vol. 130, No. 4
Stadaert-Vitse et al. Candida albicans is an immunogen of anti-Saccharomyces cerevisiae antibody marker of Crohn's disease. Gastroenterology. Vol 130, No. 6
Targan, S .; Antibodies against Cbir1 Flagelin independently define a unique response associated with Crohn's disease. Gastroenterology. Vol. 128, No. 7. Year 2005
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